mTORC1 Is Not Principally Involved in the Induction of Human Endotoxin Tolerance
Endotoxin tolerance represents a safeguard mechanism for preventing detrimental prolonged inflammation and exaggerated immune/inflammatory responses from innate immune cells to recurrent harmless pathogens.On the other hand, excessive immune tolerance can contribute to pathological immunosuppression, e.g., as present in sepsis.Monocyte activation i